Author

P. Varghese

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

U. Kishore· 4 shared K. Pondman· 2 shared R. Sim· 2 shared A. Al Aiyan· 1 shared A. Lux· 1 shared A. Mangogna· 1 shared A. S. Meyer· 1 shared B. Biswas· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersImmunology

U. Kishore

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5 papers

Recent·Most cited

The human complement factor B-C3b complex: Investigation of the interaction using C3b bound to thiol-Sepharose

S. Williams, K. Pondman, P. Varghese, A. Al Aiyan, U. Kishore, R. B. Sim

This study investigates the interaction between factor B and C3b using competition assays, finding that specific antibodies can inhibit or enhance complex formation.

bioRxiv · Jan 16, 2024 · PreprintImmunology

Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancer

U. Kishore, P. Varghese, A. Mangogna, L. Klein, M. Tu, L. Urbach, M. Qiu, R. Nicolle, V. Murugaiah, N. Beirag, S. Roth, D. Pedersen, R. Sim, V. Ellenrieder, G. R. Andersen, , S. Singh

This study shows that neutrophil-derived complement factor P induces apoptosis in basal-like pancreatic cancer cells via caspase 3/7 activation, linking properdin expression to better prognosis.

bioRxiv · Oct 28, 2023 · PreprintImmunology

Activation of Complement by Human Fibrin Clots: involvement of C1q and factor H

Y.-H. Kang, P. Varghese, K. Pondman, U. Kishore, R. Sim

This study shows fibrin clots activate the classical complement pathway, which is regulated by factor H, through covalent binding mediated by FXIIIa.

bioRxiv · Oct 19, 2023 · PreprintImmunology

Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates

Z. C. Tan, A. Lux, M. Biburger, P. Varghese, S. Lees, F. Nimmerjahn, A. S. Meyer

This study examines how mixed Fc domain immune complexes bind Fc receptors, showing blended binding profiles and refined affinity estimates for low-affinity interactions.

Cell Reports · Jul 1, 2023Peer-reviewedImmunology

A recombinant fragment of Human surfactant protein D binds Spike protein and inhibits infectivity and replication of SARS-CoV-2 in clinical samples

T. Madan, B. Biswas, P. Varghese, R. Subedi, H. Pandit, S. Idicula-Thomas, I. Kundu, S. B. Rooge, R. Aggarwal, D. Tripathi, S. Kaur, E. Gupta, S. Gupta, U. Kishore

This study shows that a recombinant fragment of human SP-D inhibits SARS-CoV-2 spike protein binding to ACE-2 and reduces viral replication in clinical samples.

bioRxiv · Dec 18, 2020Immunology