Author

A. M. D'Ordine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

Frequent Co-Authors

A. E. Conicella· 1 shared G. H. Zerze· 1 shared G. Jogl· 1 shared G. L. Dignon· 1 shared H. B. Schmidt· 1 shared J. M. Sedivy· 1 shared J. Mittal· 1 shared N. L. Fawzi· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. E. Conicella

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2 papers

Recent·Most cited

BiochemistrybioRxivDec 29, 2022

Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease

A. M. D'Ordine, G. Jogl, J. M. Sedivy

This study identifies and characterizes small molecule inhibitors of the LINE-1 retrotransposon endonuclease, showing they reduce DNA damage and inflammation in senescent cells.

DOI 10.1038/s41467-024-48066-x

humanexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivMay 18, 2019

TDP-43 α-helical structure tunes liquid-liquid phase separation and function

A. E. Conicella, G. L. Dignon, G. H. Zerze…·N. L. Fawzi

This study shows that mutations in TDP-43's helical region modulate its phase separation and function, with implications for ALS and synthetic biology.

DOI 10.1073/pnas.1912055117

humanprotein structure

𝕏 PostBluesky