G. L. Dignon

A computational procedure for predicting excipient effects on protein-protein affinities

The paper develops a computational model to predict how excipients affect protein-protein affinities by combining MD simulations and thermodynamic theory.

A predictive coarse-grained model for position-specific effects of post-translational modifications on disordered protein phase separation

This paper develops a coarse-grained model to predict how position-specific post-translational modifications affect disordered protein phase separation.

Molecular details of protein condensates probed by microsecond-long atomistic simulations

The paper uses all-atom simulations to study protein condensates, revealing structural and dynamic details of phase separation in two IDPs and showing agreement with experiments.

Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning & reduces neurodegeneration

The paper shows tyrosine phosphorylation of hnRNPA2 reduces granule component partitioning and neurodegeneration in a C. elegans model.

Hydropathy patterning complements charge patterning to describe conformational preferences of disordered proteins

The paper introduces a new order parameter, SHD, and combines it with charge patterning to predict the scaling behavior of intrinsically disordered proteins from their sequences.

Identifying Sequence Perturbations to an Intrinsically Disordered Protein that Determine Its Phase Separation Behavior

This study identifies sequence features of an intrinsically disordered protein that influence its phase separation behavior through computational modeling and experimental validation.

TDP-43 α-helical structure tunes liquid-liquid phase separation and function

This study shows that mutations in TDP-43's helical region modulate its phase separation and function, with implications for ALS and synthetic biology.

Sequence determinants of protein phase behavior from a coarse-grained model

This paper develops a coarse-grained computational model to simulate liquid-liquid phase separation of proteins, showing it can capture phase diagram changes due to mutations and domain presence.