Author

H. B. Schmidt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Approach:biophysical modeling· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Organism:yeast· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

R. Rohatgi· 4 shared A. A. Covarrubias· 1 shared A. Barreau· 1 shared A. Briner· 1 shared A. D. Gitler· 1 shared A. Das· 1 shared A. E. Conicella· 1 shared A. Ekman· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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4 shared papersCell Biology

R. Rohatgi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Direct ionic stress sensing and mitigation by the transcription factor NFAT5

C. B. Khandwala, P. Sarkar, H. B. Schmidt, M. Ma, M. Kinnebrew, G. V. Pusapati, B. B. Patel, D. Tillo, A. M. Lebensohn, R. Rohatgi

This study identifies NFAT5 as a direct sensor and effector of ionic stress in animal cells, showing it forms condensates to activate genes restoring ion balance.

bioRxiv · Sep 23, 2023Cell Biology

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

S. Boeynaems, X. R. Ma, V. Yeong, G. M. Ginell, J.-H. Chen, J. A. Blum, L. Nakayama, A. Sanyal, A. Briner, D. Van Haver, J. Pauwels, A. Ekman, H. B. Schmidt, K. Sundararajan, L. Porta, , A. D. Gitler

The paper identifies a common toxic mechanism in positively charged peptides across species and develops a machine learning tool to detect it.

bioRxiv · Mar 9, 2023 · PreprintCell Biology

Oxaliplatin kills cells via liquid-liquid demixing of nucleoli

H. B. Schmidt, Z. A. Jaafar, J. J. Rodencal, M. D. Leonetti, S. J. Dixon, R. Rohatgi, O. Brandman

This study shows oxaliplatin causes nucleolar liquid-liquid demixing, leading to cell death by disrupting nucleolar organization and transcription.

bioRxiv · Jun 10, 2021 · PreprintCell Biology

Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells

C. L. Cuevas-Velazquez, T. Vellosillo, K. Guadalupe, H. B. Schmidt, F. Yu, D. Moses, J. A. Brophy, D. Cosio-Acosta, A. Das, L. Wang, A. M. Jones, A. A. Covarrubias, S. Sukenik, J. R. Dinneny

The paper develops a FRET biosensor using intrinsically disordered proteins to monitor osmotic stress effects across multiple organisms.

bioRxiv · Feb 17, 2021Cell Biology

TDP-43 α-helical structure tunes liquid-liquid phase separation and function

A. E. Conicella, G. L. Dignon, G. H. Zerze, H. B. Schmidt, A. M. D'Ordine, Y. C. Kim, R. Rohatgi, Y. M. Ayala, J. Mittal, N. L. Fawzi

This study shows that mutations in TDP-43's helical region modulate its phase separation and function, with implications for ALS and synthetic biology.

bioRxiv · May 18, 2019Biochemistry

Decoding and recoding phase behavior of TDP43 reveals that phase separation is not required for splicing function

H. B. Schmidt, A. Barreau, R. Rohatgi

The paper shows that TDP43's splicing function does not require phase separation, using mutagenesis and live-cell assays to analyze phase dynamics.

bioRxiv · Feb 13, 2019 · PreprintCell Biology