ImmunologybioRxiv
Complement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.
A. J. Wood, A. M. Vassallo, M.-H. Ruchard-Sparagano…·A. Conway Morris
This study identifies C5a-induced phosphoproteomic changes in human neutrophils that impair phagosomal maturation and acidification, leading to reduced killing of Staphylococcus aureus.
DOI 10.1172/jci.insight.137029