Author

C. Summers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

E. R. Chilvers· 2 shared A. Condliffe· 1 shared A. Conway Morris· 1 shared A. Higuera· 1 shared A. J. Simpson· 1 shared A. J. Wood· 1 shared A. M. Vassallo· 1 shared A. Y. Ng· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

E. R. Chilvers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Efficient methods for target gene manipulation in haematopoietic stem cell derived human neutrophils.

A. Y. Ng, E. Fox, J. Brelstaff, M. Frontini, C. Summers

The paper presents a method to genetically manipulate human neutrophils derived from haematopoietic progenitors, showing CD11b is not required for phagocytosis of opsonized bacteria.

bioRxiv · Jun 17, 2023 · PreprintCell Biology

Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice

W. Li, L. Long, X. Yang, Z. Tong, M. Southwood, P. Caruso, P. D. Upton, P. Yang, G. Bocobo, I. Nikolic, A. Higuera, R. Salmon, H. Jiang, K. Lodge, K. Hoenderdos, , N. W. Morrell

This study shows that BMP9 protects pulmonary endothelium during inflammation-induced lung injury and that exogenous BMP9 can prevent lung injury in mice.

bioRxiv · May 12, 2020Physiology

Complement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.

A. J. Wood, A. M. Vassallo, M.-H. Ruchard-Sparagano, J. Scott, C. Zinnato, C. Gonzalez-Tejedo, K. Kishore, C. D'Santos, A. J. Simpson, D. Menon, C. Summers, E. R. Chilvers, K. Okkenhaug, A. Conway Morris

This study identifies C5a-induced phosphoproteomic changes in human neutrophils that impair phagosomal maturation and acidification, leading to reduced killing of Staphylococcus aureus.

bioRxiv · Jan 17, 2020Immunology