ImmunologyScience ImmunologyPeer-reviewed
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity
B. Klein, M. B. Reynolds, B. Xu…·J. M. Kahlenberg
The paper identifies ZBP1 and mitochondrial Z-DNA as drivers of autoimmune photosensitivity through cGAS-STING activation in response to UVB.
DOI 10.1126/sciimmunol.ado1710