Author

B. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. M. Kahlenberg· 2 shared M. B. Reynolds· 2 shared M. X. O'Riordan· 2 shared A. M. Victory· 1 shared A. S. Riching· 1 shared B. C. Michmerhuizen· 1 shared B. Xu· 1 shared C. A. Lyssiotis· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

J. M. Kahlenberg

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity

B. Klein, M. B. Reynolds, B. Xu, M. Gharaee-Kermani, Y. Gao, C. C. Berthier, S. Henning, S. N. Loftus, K. E. McNeely, A. M. Victory, C. J. Dobry, G. A. Hile, F. Ma, J. L. Turnier, J. E. Gudjonsson, , J. M. Kahlenberg

The paper identifies ZBP1 and mitochondrial Z-DNA as drivers of autoimmune photosensitivity through cGAS-STING activation in response to UVB.

Science Immunology · Mar 7, 2025Peer-reviewedImmunology

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection

M. B. Reynolds, B. Klein, M. J. McFadden, N. K. Judge, H. E. Navarrete, B. C. Michmerhuizen, D. Awad, T. L. Schultz, P. W. Harms, L. Zhang, T. R. O'Meara, J. Z. Sexton, C. A. Lyssiotis, J. M. Kahlenberg, M. X. O'Riordan

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

bioRxiv · Jan 10, 2024 · PreprintImmunology

Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis

A. S. Riching, E. Danis, Y. Zhao, Y. Cao, C. Chi, R. Bagchi, B. Klein, H. Xu, T. Kutateladze, T. McKinsey, P. Buttrick, K. Song

The paper identifies how TGF-β signaling inhibition allows GATA4 to interact with JMJD3, promoting cardiomyogenesis by demethylating H3K27me3 at cardiac gene promoters.

bioRxiv · Feb 12, 2020Cell Biology