This study investigates the mechanism of N1303K-CFTR rescue by ELX/TEZ and ETI combotherapy, showing increased protein amounts and activity with potential clinical benefits.

bioRxiv · Feb 29, 2024 · PreprintPhysiology

Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes

S. Zhu, E. Waeckel-Enee, A. Moser, M.-A. Bessard, K. Roger, J. Lipecka, A. Yilmaz, B. Bertocci, J. Diana, B. Saintpierre, I. C. Guerrera, S. Francesconi, F.-X. Mauvais, P. van Endert

This study shows that IDE deficiency in mice causes a low-level UPR, enhances beta cell proliferation, and protects against autoimmune diabetes through an anti-inflammatory pathway.

bioRxiv · Jul 19, 2023 · PreprintCell Biology

mTOR Inhibition Suppresses Salinomycin-Induced Ferroptosis in Breast Cancer Stem Cells by Ironing Out Mitochondrial Dysfunctions

E. Cosialls, E. Pacreau, S. Ceccacci, R. Elhage, C. Duruel, C. Desterke, K. Roger, C. Guerrera, R. Ducloux, S. Souquere, G. Pierron, I. Nemazanyy, M. Kelly, E. Dalmas, Y. Chang, , A. Hamai

The paper shows that mTOR inhibition reduces Salinomycin-induced ferroptosis in breast cancer stem cells by modulating iron flux and mitochondrial function.

bioRxiv · May 2, 2023Cancer Biology