Dysregulated Protein Translation Control in Hidradenitis Suppurativa: Implication for Lesion-associated Squamous Cell Carcinoma Development
L. Jin, M. P. Kashyap, Y. Chen, Y. Guo, J. Khan, J. Q. Chen, M. B. Lee, A. Oak, R. Sinha, M. S. Mukhtar, J. S. Deshane, C. Raman, C. A. Elmets, M. Athar
This study identifies dysregulated eIF4F translation initiation complex in HS lesions, linking it to SCC development through Cyclin D1 and c-Myc overexpression.
bioRxiv · Oct 14, 2021 · PreprintCancer Biology