J. Khan

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

High-throughput Approaches to Uncover Synergistic Drug Combinations in Leukemia

This paper identifies synergistic drug combinations in AML using high-throughput methods and open-source tools, revealing synergies affecting histone H3 lysine-27 modification.

Transcriptomics based prediction of survival and response to therapy in malignant mesothelioma

The paper identifies a 48-gene prognostic signature and synthetic-lethality profiles predictive of survival and therapy response in mesothelioma using transcriptomic and exomic data from 122 patients.

Dysregulated Protein Translation Control in Hidradenitis Suppurativa: Implication for Lesion-associated Squamous Cell Carcinoma Development

This study identifies dysregulated eIF4F translation initiation complex in HS lesions, linking it to SCC development through Cyclin D1 and c-Myc overexpression.

Ex Vivo Culture Models of Hidradenitis Suppurativa for defining molecular pathogenesis and treatment efficacy of novel drugs

This paper develops three ex vivo skin culture models for HS to study molecular pathogenesis and drug efficacy.

SNAI2-mediated direct repression of BIM protects rhabdomyosarcoma from ionizing radiation

This study identifies SNAI2 as a repressor of BIM, protecting rhabdomyosarcoma from ionizing radiation through a P53-independent mechanism.

Proteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma

The paper identifies HLA Class I-presented peptides in melanoma and EGFR mutant lung adenocarcinoma using proteogenomic analysis, revealing neopeptides and post-translationally modified peptides for potential immunotherapy.

Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation

This study identifies lineage-specific transcription factors and super-enhancers driving neuroblastoma self-renewal and differentiation using ATRA treatment and CRISPR screening.

Computational vaccinology based development of multi-epitope subunit vaccine for protection against the Norovirus infections

This study develops a multi-epitope subunit vaccine against Norovirus using computational vaccinology, selecting antigenic epitopes and modeling the vaccine structure for potential experimental validation.

Biosynthesis of Iron Oxide Nanoparticles via Crocus sativus and their Antifungal Efficacy against Verticillium Wilt Pathogen Verticillium dahliae

This study synthesizes iron oxide nanoparticles using Crocus sativus and evaluates their antifungal activity against Verticillium dahliae, showing significant inhibition of fungal growth.

Miswired enhancer logic drives translocation positive rhabdomyosarcoma

The paper identifies a miswired enhancer logic driven by PAX3-FOXO1 translocation in rhabdomyosarcoma, disrupting normal transcription factor regulation and promoting undifferentiated proliferation.

Integrated proteogenomic analysis of metastatic thoracic tumors identifies APOBEC mutagenesis and copy number alterations as drivers of proteogenomic tumor evolution and heterogeneity