Author

M. Athar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. A. Elmets· 3 shared L. Jin· 3 shared M. P. Kashyap· 3 shared M. S. Mukhtar· 3 shared R. Sinha· 3 shared C. Raman· 2 shared J. Khan· 2 shared J. S. Deshane· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

C. A. Elmets

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Predicting binding events in very flexible, allosteric, multi-domain proteins

A. Basciu, M. Athar, H. Kurt, C. Neville, G. Malloci, F. Muredda, A. Bosin, P. Ruggerone, A. Bonvin, A. V. Vargiu

This paper introduces a method to generate bound-like conformations of flexible, multi-domain proteins using unbound structures and binding site information, demonstrating its effectiveness on adenylate kinase.

bioRxiv · Jun 2, 2024Biophysics

Cathepsin B regulates ovarian reserve quality and quantity via mitophagy by modulating IGF1R turnover.

A. Mohanty, A. Kumari, L. Kumar. S, A. Kumar, P. Birajdar, R. Beniwal, M. Athar, K. Kumar P, H. Prasada Rao

This study identifies Cathepsin B's role in regulating ovarian reserve through mitophagy and IGF1R turnover, showing its conservation in higher vertebrates.

bioRxiv · Feb 14, 2024Cell Biology

NK and NKT cells in the pathogenesis of Hidradenitis suppurativa: Novel therapeutic strategy through targeting of CD2

M. P. Kashyap, B. Mishra, R. Sinha, L. Jin, N. Kumar, K. F. Goliwas, J. Deshane, B. E. Elewski, C. A. Elmets, M. Athar, M. S. Mukhtar, C. Raman

This study identifies expanded NKT and NK cells with elevated CD2 in HS lesions and shows CD2 blockade reduces inflammation and fibrosis.

bioRxiv · Oct 31, 2023 · PreprintImmunology

Mass cytometry identifies dysregulation of circulating and cutaneous immune cells in patients with hidradenitis suppurativa

P. Dimitrion, I. Hamzavi, C. Yin, I. Loveless, J. Toor, K. Subedi, N. Khalasawi, A. Miller, R. Huggins, I. Adrianto, J. Veenstra, G. Vellaichamy, A. Hans, S. Daveluy, M. Athar, , Q.-S. Mi

This study identifies immune cell dysregulation in hidradenitis suppurativa using mass cytometry and RNA-seq, finding increased CD38 expression in monocytes and suggesting CD38 as a therapeutic target.

bioRxiv · Jan 27, 2023 · PreprintImmunology

Dysregulated Protein Translation Control in Hidradenitis Suppurativa: Implication for Lesion-associated Squamous Cell Carcinoma Development

L. Jin, M. P. Kashyap, Y. Chen, Y. Guo, J. Khan, J. Q. Chen, M. B. Lee, A. Oak, R. Sinha, M. S. Mukhtar, J. S. Deshane, C. Raman, C. A. Elmets, M. Athar

This study identifies dysregulated eIF4F translation initiation complex in HS lesions, linking it to SCC development through Cyclin D1 and c-Myc overexpression.

bioRxiv · Oct 14, 2021 · PreprintCancer Biology

Ex Vivo Culture Models of Hidradenitis Suppurativa for defining molecular pathogenesis and treatment efficacy of novel drugs

K. Goliwas, M. P. Kashyap, J. Khan, R. Sinha, Z. Weng, A. S. Oak, L. Jin, V. Attigadda, M. B. Lee, C. A. Elmets, M. S. Mukhtar, J. S. Deshane, M. Athar

This paper develops three ex vivo skin culture models for HS to study molecular pathogenesis and drug efficacy.

bioRxiv · Oct 11, 2021Pathology

Exploring Ruthenium-based organometallic inhibitors against Plasmodium Calcium Dependent Kinase 2 (PfCDPK2): a combined ensemble docking, QM paramterization and molecular dynamics study

D. D. Patel, M. Athar, P. C. Jha

This study uses computational methods to evaluate ruthenium-based organometallic inhibitors against PfCDPK2, finding E52 and FLL have better affinity than staurosporine.

bioRxiv · Mar 31, 2020Biochemistry