Author

A. Ottria

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. J. Affandi· 2 shared M. Cossu· 2 shared T. Carvalheiro· 2 shared T. R. D. J. Radstake· 2 shared A. C. Hinrichs· 1 shared A. Pandit· 1 shared A. S. Meijers· 1 shared B. Giovannone· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

A. J. Affandi

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

T. Carvalheiro, W. Marut, M. I. Pascoal Ramos, S. Garcia, D. Fleury, A. J. Affandi, A. S. Meijers, B. Giovannone, R. G. Tieland, E. Elshof, A. Ottria, M. Cossu, M. L. Meizlish, T. Veenendaal, M. Ramanujam, , L. Meyaard

The paper investigates how impaired LAIR-1-collagen interaction in fibrosis contributes to inflammation and fibrosis, finding that dysfunctional collagen ligands and matrix metalloproteinases drive disease progression.

bioRxiv · Dec 7, 2021Immunology

Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis

N. H. Servaas, S. Hiddingh, E. Chouri, C. G. K. Wichers, A. J. Affandi, A. Ottria, C. P. J. Bekker, M. Cossu, S. Silva-Cardoso, M. van der Kroef, A. C. Hinrichs, T. Carvalheiro, N. Vazirpanah, L. Beretta, M. Rossato, , A. Pandit

This study identifies NR4A nuclear receptor subfamily genes as key regulators of immune and fibrosis pathways in SSc cDC2s through transcriptomic and network analysis, with functional validation using ChIP-sequencing and in vitro experiments.

bioRxiv · Nov 8, 2021Immunology