A. Pandit

Integrating fish biology, population genomics and fishery policies for informed management of interjurisdictional multi-species fisheries

The paper introduces IRIIS, a framework that integrates population genomics, fish biology, and fisheries policies to assess overexploitation risk in interjurisdictional fisheries.

Unravelling the glycome in human intervertebral disc degeneration: Aberrant glycosylation modulates inflammation and metabolism.

This study identifies hypersialylation in intervertebral disc degeneration and shows it modulates inflammation and metabolism.

Reproducing extracellular matrix adverse remodelling of non-ST myocardialinfarction in a large animal model

This paper develops an ovine model of NSTEMI and identifies ECM and glycan alterations in post-ischaemic tissue.

Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

The paper identifies persistent, antigen-specific T cell clones in JIA joints and circulation, suggesting antigen-driven expansion of both Tregs and Teffector cells.

Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

The paper identifies CX3CR1-positive type 3 dendritic cells as implicated in non-infectious uveitis through transcriptome network analysis and flow cytometry.

Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis

This study identifies NR4A nuclear receptor subfamily genes as key regulators of immune and fibrosis pathways in SSc cDC2s through transcriptomic and network analysis, with functional validation using ChIP-sequencing and in vitro experiments.

Analysis of the Neurotropic and Anti-inflammatory Effects of Neuroelectrode Functionalization with a Heparan Sulphate Mimetic

This study functionalizes neural electrodes with a heparan sulphate mimetic to reduce glial scar formation and promote neural outgrowth in vitro.

The molecular pH-response mechanism of the plant light-stress sensor PsbS

This study investigates how PsbS, a plant light-stress sensor, responds to low pH through spectroscopic analysis, revealing a conformational switch mechanism.

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscape

The paper identifies a conserved human effector Treg signature through transcriptomic and epigenetic analysis, showing overlap with tumor-infiltrating Treg and environment-driven adaptations.

Conformational dynamics of photosynthetic Light-Harvesting Complex II in a native membrane environment

This study uses solid-state NMR to analyze conformational dynamics of LHCII in native thylakoid membranes, identifying flexible sites and reduced dynamics in native organelles.

Self-powered piezo-bioelectronic device mediates tendon repair through modulation of mechanosensitive ion channels.

This study demonstrates a self-powered piezo-bioelectronic device that modulates mechanosensitive ion channels to promote tendon repair in a rat model.

Temporal Changes Guided by Mesenchymal Stem Cells on a 3D Microgel Platform Enhances Angiogenesis In Vivo at a Low-Cell Dose

This study shows that preconditioning mesenchymal stem cells on a 3D microgel platform enhances angiogenesis in vivo at a low-cell dose by modulating extracellular stiffness and integrin signaling.

Local intracerebral Inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo.

The paper develops a novel immunocompetent GBM model to test the effect of IRE1 inhibition on treatment efficacy in vivo.

Novel IRE1-dependent proinflammatory signaling controls tumor infiltration by myeloid cells.

This study identifies an IRE1-dependent proinflammatory signaling pathway in glioblastoma that promotes tumor invasion, angiogenesis, and myeloid cell infiltration.

Constitutive UPRER activation sustains tumor cell differentiation

The paper shows that constitutive IRE1 activation maintains differentiation in glioblastoma cells by repressing stemness factors.

Time-resolved fluorescence analysis of LHCII in the presence of PsbS at neutral and low pH

This study investigates the effect of low pH and PsbS on LHCII fluorescence lifetimes in spinach proteoliposomes, finding no significant impact on Chl excited-state lifetimes.