BiophysicsbioRxivPreprint
The HCM-Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC-cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation
M. L. Lynn, J. Jimenez, R. L. Castillo…·J. C. Tardiff
This paper investigates how the HCM-linked mutation Arg92Leu in TNNT2 alters the cTnC-cTnI interface, impairing PKA access and causing early diastolic dysfunction.
DOI 10.1101/2023.07.18.549569