Author

C. Gibson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 2 Bioinformatics· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:metagenomics· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:proteomics· 2

Frequent Co-Authors

B. Guo· 4 shared D. Frigon· 4 shared N. Klai· 2 shared N. Klimova· 2 shared S. A. Kraemer· 2 shared A. Evans· 1 shared A. M. Murphy· 1 shared A. P. Baldo· 1 shared

Activity by Year

2022-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersMicrobiology

B. Guo

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Human coronavirus HKU1 recognition of the TMPRSS2 host receptor

M. McCallum, Y.-J. Park, C. Stewart, K. R. Sprouse, J. Brown, M. A. Tortorici, C. Gibson, E. Wong, M. Ieven, A. Telenti, D. Veesler

This study determines the structure of HKU1 spike RBD bound to TMPRSS2, identifies host receptor usage determinants, and shows the role of antibodies and glycan shielding in neutralization.

Cell · Aug 1, 2024Peer-reviewedBiochemistry

AutoXAI4Omics: an Automated Explainable AI tool for Omics and tabular data

J. Strudwick, L.-J. Gardiner, K. Denning-James, N. Haiminen, A. Evans, J. Kelly, M. Madgwick, F. Utro, E. Seabolt, C. Gibson, B. Bedi, D. Clayton, C. Howell, L. PARIDA, A. P. Carrieri

AutoXAI4Omics automates and explains ML pipelines for omics and tabular data, enabling interpretable insights for biomarker discovery and phenotype prediction.

bioRxiv · Mar 25, 2024 · PreprintBioinformatics

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

N. Zhang, J. Wu, F. Hossain, H. Peng, H. Li, C. Gibson, M. Chen, H. Zhang, S. Gao, X. Zheng, Y. Wang, J. Zhu, J. J. Wang, I. Maze, Q. Zheng

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

bioRxiv · Mar 20, 2024Biochemistry

Development of Ingenui-T, a Novel Vein-to-Vein Solution for Rapid Autologous CAR T-Cell Manufacturing Starting From Whole Blood, for the Treatment of Autoimmune Diseases

D. Anaya, B. Kwong, S. Park, S. Biswas, J. Jeevan, M. Strobach, N. Khoshnoodi, A. Register, T. Klasson, S. Foos-Russ, J. Zeng, J. Banuelos, C. Gibson, J. Bravo, J. Flandez, , K. Walker

This paper introduces Ingenui-T, a method for rapid CAR T-cell manufacturing from whole blood, showing comparable or better functional activity than conventional methods.

bioRxiv · Jan 24, 2024 · PreprintImmunology

The HCM-Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC-cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation

M. L. Lynn, J. Jimenez, R. L. Castillo, M. M. Klass, C. Vasquez, A. P. Baldo, C. Gibson, A. M. Murphy, J. C. Tardiff

This paper investigates how the HCM-linked mutation Arg92Leu in TNNT2 alters the cTnC-cTnI interface, impairing PKA access and causing early diastolic dysfunction.

bioRxiv · Jul 18, 2023 · PreprintBiophysics

Multiplexed Amplicon Sequencing Reveals High Sequence Diversity of Antibiotic Resistance Genes in Quebec Sewers

C. Gibson, S. A. Kraemer, N. Klimova, L. Vanderweyen, N. Klai, E. Diaz Mendoza, B. Guo, D. A. Walsh, D. Frigon

This study uses multiplexed amplicon sequencing to detect sequence variants of antibiotic resistance genes in Quebec sewers, revealing high diversity and varying public health risks.

bioRxiv · Mar 6, 2023 · PreprintMicrobiology

Antibiotic Resistance Gene Variant Sequencing is Necessary to Reveal the Complex Dynamics of Immigration from Sewers to Activated Sludge

C. Gibson, S. A. Kraemer, N. Klimova, B. Guo, D. Frigon

This study investigates ARG immigration dynamics between sewers and activated sludge using sequencing and PCR to show that over 70% of ARGs increase in abundance due to immigration.

bioRxiv · Mar 5, 2023Microbiology

Activated Sludge Microbial Community Assembly: The Role of Influent Microbial Community Immigration

C. Gibson, S. Jauffur, B. Guo, D. Frigon

This study investigates how influent microbial immigration affects activated sludge communities in wastewater treatment plants, finding that immigrants contribute up to 25% of sequencing reads.

bioRxiv · Jan 25, 2023Microbiology

Wastewater Influent Microbial Immigration and Contribution to Resource Consumption in Activated Sludge Using Taxon-Specific Mass-Flow Immigration Model

B. Guo, C. Liu, C. Gibson, N. Klai, X. Lin, D. Frigon

The paper develops a mass-flow immigration model to quantify influent microorganism immigration efficiency and their contribution to organic substrate consumption in activated sludge.

bioRxiv · Aug 15, 2022 · PreprintMicrobiology