The HCM-Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC-cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation
M. L. Lynn, J. Jimenez, R. L. Castillo, M. M. Klass, C. Vasquez, A. P. Baldo, C. Gibson, A. M. Murphy, J. C. Tardiff
This paper investigates how the HCM-linked mutation Arg92Leu in TNNT2 alters the cTnC-cTnI interface, impairing PKA access and causing early diastolic dysfunction.
bioRxiv · Jul 18, 2023 · PreprintBiophysics