PhysiologybioRxivPreprint
High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells
F. Cuozzo, K. Viloria, A. H. Shilleh…·D. J. Hodson
The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.