C. Ludwig

Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase

This study shows that butyrate is metabolized into the TCA cycle in fly heads and increases oxygen consumption without affecting proteome or acetylome.

ARID1A Mutations Protect Follicular Lymphoma from FAS-dependent Immune Surveillance by Reducing RUNX3/ETS1-Driven FAS-Expression

This study identifies ARID1A mutations in follicular lymphoma that reduce FAS expression, enabling immune evasion by disrupting RUNX3/ETS1 regulation.

Regulation of adaptive growth decisions via phosphorylation of the TRAPPII complex in Arabidopsis

This study shows that phosphorylation of the TRAPPII complex by AtSKs regulates adaptive growth responses in Arabidopsis under stress conditions.

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

Overexpression of the plastidal pseudo-protease AtFtsHi3 confers drought tolerance without penalizing growth

This study shows overexpression of AtFtsHi3 in Arabidopsis improves drought tolerance without affecting growth by altering stomatal density and enhancing water use efficiency.

Convergent evolution of plant pattern recognition receptors sensing cysteine-rich patterns from three microbial kingdoms

The paper identifies a cysteine-rich pattern recognized by plant receptors from three microbial kingdoms, showing convergent evolution of immune responses.

Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan

The paper demonstrates that increasing mitochondrial membrane potential in C. elegans using a light-activated proton pump extends lifespan and reverses age-related phenotypes.

Shadow ORFs illuminated: long overlapping genes in Pseudomonas aeruginosa are translated and under purifying selection

The paper identifies two long overlapping genes in Pseudomonas aeruginosa that are translated and under purifying selection, expanding understanding of prokaryotic genomic complexity.

Biophysical and proteomic analyses suggest functions of Pseudomonas syringae pv tomato DC3000 extracellular vesicles in bacterial growth during plant infection

This study identifies proteins in extracellular vesicles of Pseudomonas syringae pv. tomato DC3000 and suggests their roles in bacterial growth and plant infection.

RGI-GOLVEN signalling promotes FLS2 abundance to regulate plant immunity

This study identifies GLV2 peptides as phytocytokines in Arabidopsis that enhance plant immunity by increasing FLS2 abundance through RGI receptor signaling.

Nucleolar TFIIE plays a role in ribosomal biogenesis and performance

This study identifies TFIIE's role in ribosomal RNA synthesis and shows that mutations impair ribosomal biogenesis, leading to proteostasis loss and TTD symptoms.

Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation

This study identifies fumarate accumulation driven by purine nucleotide cycle activity as a cause of macrovesicular steatosis in NAFLD using human pluripotent stem cell-derived hepatocytes.

Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic

The paper identifies and characterizes ORF3d, a novel overlapping gene in SARS-CoV-2, showing its presence in pangolin-CoVs and its evolutionary significance.

Dietary intervention improves health metrics and life expectancy of the genetically obese DU6 (Titan) mouse

The study characterizes the Titan mouse as a model for metabolically unhealthy obesity and shows that dietary intervention improves its health and extends lifespan.

T-ALL Proliferation Relies on Glutamine Uptake and EAAT1-dependent Conversion of Glutamine to Aspartate and Nucleotides

This study identifies EAAT1 as a critical target for T-ALL treatment by showing its role in glutamine conversion to nucleotides and aspartate essential for cell proliferation.

ShearFAST: a user-friendly in vitro toolset for high throughput, inexpensive fluid shear stress experiments.

ShearFAST is a smartphone app that measures fluid shear stress in cell rockers, validated against motion tracking systems with high correlation.