Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism
S. Khadka, Y.-H. Lin, J. J. Ackroyd, Y.-A. Chen, Y. Sheng, W. Qian, S. Guo, Y. Chen, E. I. Behr, Y. Barekatain, M. N. Uddin, K. Arthur, V. C. Yan, E. Chang, A. Poral, , F. L. Muller
This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.
bioRxiv · May 7, 2023 · PreprintCancer Biology