Author

F. P. Barthel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Assay:DNA methylation· 2

Frequent Co-Authors

K. C. Johnson· 3 shared R. G. Verhaak· 3 shared F. S. Varn· 2 shared H. Kim· 2 shared K. J. Anderson· 2 shared P. Wesseling· 2 shared A. B. Heimberger· 1 shared A. D. Miller· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

K. C. Johnson

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5 papers

Recent·Most cited

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

S. Khadka, Y.-H. Lin, J. J. Ackroyd, Y.-A. Chen, Y. Sheng, W. Qian, S. Guo, Y. Chen, E. I. Behr, Y. Barekatain, M. N. Uddin, K. Arthur, V. C. Yan, E. Chang, A. Poral, , F. L. Muller

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

bioRxiv · May 7, 2023 · PreprintCancer Biology

Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment

F. S. Varn, K. C. Johnson, T. E. Wade, T. M. Malta, T. S. Sabedot, F. P. Barthel, H. Kim, N. Ahmed, I. Datta, J. S. Barnholtz-Sloan, S. Bakas, F. D'Angelo, H. K. Gan, L. Garofano, J. T. Huse, , The GLASS Consortium

This study analyzes longitudinal glioma data to identify recurrence-associated changes in genetics and microenvironment linked to therapy resistance.

bioRxiv · May 3, 2021Cancer Biology

DNA methylation classification in diffuse glioma shows little spatial heterogeneity after adjusting for tumor purity

N. Verburg, F. P. Barthel, K. J. Anderson, K. C. Johnson, M. Koopman, M. Yaqub, O. Hoekstra, A. Lammertsma, F. Barkhof, P. Pouwels, J. C. Reijneveld, A. Rozemuller, R. Boellaard, M. D. Taylor, S. Das, , R. G. Verhaak

This study shows DNA methylation subtypes in diffuse gliomas are spatially consistent after adjusting for tumor purity, indicating inherent cellular heterogeneity rather than tumor-specific variation.

bioRxiv · Mar 28, 2020 · PreprintCancer Biology

Comparative molecular life history of spontaneous canine and human gliomas

S. B. Amin, K. J. Anderson, C. E. Boudreau, E. Martinez-Ledesma, E. Kocavakuk, K. C. Johnson, F. P. Barthel, F. S. Varn, C. Kassab, X. Ling, H. Kim, M. Barter, C. Y. Ngan, M. Chapman, J. W. Koehler, , R. G. Verhaak

This study compares molecular profiles of canine and human gliomas to identify conserved mutational processes and similarities in tumor development.

bioRxiv · Jun 17, 2019Cancer Biology

TumorFusions: an integrative resource for reporting cancer-associated transcript fusions in 33 tumor types

X. Hu, Q. Wang, F. P. Barthel, M. Tang, S. Amin, K. Yoshihara, F. M. Lang, S. H. Lee, S. Zheng, R. Verhaak

The paper reports cancer-associated transcript fusions in 33 tumor types using TCGA data and provides a resource for accessing the results.

bioRxiv · Jul 11, 2017Cancer Biology