Y. Sheng

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

Asymmetric binding of coactivator SRC1 to FXR-RXR and allosteric communication within the complex

This study reveals the asymmetric binding of SRC1 to FXR-RXR and the allosteric communication within the complex, providing a structural model for understanding FXR function and its disease implications.

Are the Next-Generation Pathogenicity Predictors Applicable to Cancer?

This study evaluates next-generation pathogenicity predictors for cancer driver mutation detection, finding they perform well but lack specificity for cancer types.

Geometry theory of distribution shapes for autoregulatory gene circuits

This study mathematically characterizes the phase diagram of protein distribution shapes in autoregulatory gene circuits, identifying three steady-state shapes and their parameter regions.

Coordinated molecular and ecological adaptations underlie a highly successful parasitoid

This study identifies molecular and ecological adaptations in the parasitoid Trichopria drosophilae that enhance its success in parasitizing Drosophila hosts.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

This study determines the native structure of ChAdOx1-vectored SARS-CoV-2 vaccines on cell surfaces, showing prefusion spikes in one-RBD-up conformation and improved RBD exposure in HexaPro-stabilized variants.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

Temporal colonization of the gut microbiome in neonatal Bos taurus at single nucleotide resolution

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

Simulating the Tumor Microenvironment for Immune Cell Interactions via Deployable Extrusion Bioprinting

The paper introduces a deployable extrusion bioprinting platform for creating 3D tumor microenvironments to study immune cell interactions and cancer drug testing.

Single residue substitution in protamine 1 disrupts sperm genome packaging and embryonic development in mice

This study shows that a single amino acid substitution in mouse protamine 1 disrupts DNA packaging and causes infertility by altering protein function and developmental outcomes.

Cell minor-axis length is a critical feature for breast cancer cell migration on straight, wavy, loop and grid microfibre patterns

This study shows that breast cancer cells' migration on microfiber patterns is limited by their minor-axis length, suggesting this feature could guide microfiber design for controlling cell movement.

SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging

This study uses cryo-imaging to reveal SARS-CoV-2 replication, assembly, and egress pathways in infected cells.

Genome-wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells

This study shows ARID1A has opposite roles in promoting neural differentiation and suppressing cardiac differentiation from human pluripotent stem cells.

Dipeptidyl dipeptidase-4 inhibitor, MK-0626, promotes bone marrow-derived endothelial progenitor cell bioactivities for vascular regeneration in diet-induced obese mice

This study shows that MK-0626, a DPP-4 inhibitor, improves EPC bioactivity and reduces inflammation in diet-induced obese mice with ischemia.

Genomic analysis for heavy metal resistance in S. maltophilia

This study sequenced and analyzed the genome of S. maltophilia Pho to identify heavy metal resistance mechanisms, revealing transporter genes, efflux systems, and detoxification genes.