E. Chang

Stretching the structural envelope of isomeric imatinib analogs that reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP

The paper investigates how structurally diverse imatinib analogs affect APP metabolism similarly, identifying potent isomers for further development.

Eubacterium rectale detoxification mechanism increases resilience of the gut environment

This study identifies Eubacterium rectale's detoxification mechanism, showing its ability to reduce ROS and inflammation in gut cells through glutathione production.

Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.

Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.

Microbially-catalyzed conjugation of GABA and tyramine to bile acids

The paper identifies bacteria that conjugate GABA and tyramine to bile acids in the human gut and shows these conjugates are present in stool and J-pouch contents.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolopyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2

The paper develops analogs of SGC-CK2-1 to improve pharmacokinetic properties in mice by inhibiting GST and P450 enzymes through co-dosing protocols.

Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient

This study identifies genes and pathways in B. fragilis that affect its fitness in bile acids, using a barcoded mutant library and transcriptomic analysis.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

Rational development of a small-molecule activator of CK1γ2 that decreases C99 and beta-amyloid levels

This study identifies CK1γ2 as a therapeutic target for Alzheimer's disease by showing its activation reduces C99 and beta-amyloid levels through increased PS1-Ser367 phosphorylation.

Sustained Delivery of GLP-1 Receptor Agonists from Injectable Biomimetic Hydrogels Improves Treatment of Diabetes

This paper develops a hydrogel-based GLP-1 receptor agonist delivery system that provides sustained therapy for up to 42 days in rats, improving diabetes management compared to daily injections.

Dynamic genetic adaptation of Bacteroides thetaiotaomicron murine gut colonization

This study tracks genetic and metabolic changes in Bacteroides thetaiotaomicron during gut colonization, showing shifting gene usage and highlighting the importance of carbohydrate metabolism for long-term persistence.

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

The paper shows that inhibiting the kinase CSNK2 blocks replication of several beta-coronaviruses, including SARS-CoV-2, by preventing viral entry.

Clinical and immunological signatures of severe COVID-19 in previously healthy patients with clonal hematopoiesis

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

Ciliary IFT88 safeguards coordinated epiphyseal vascularisation, resorption and ossification from disruptive physiological mechanical forces

This study shows that IFT88 in cilia protects growth plate ossification from mechanical forces by regulating vascularization and resorption in adolescent mice.

Secretion of redox-active metabolites as a general strategy for iron acquisition in plants

This study identifies sideretin, a redox-active metabolite secreted by Arabidopsis roots under iron deficiency, and shows its role in iron acquisition through reduction, suggesting a widespread strategy in eudicots.