BiochemistrybioRxiv
Zinc shapes the folding landscape of p53 and establishes a new pathway for reactivating structurally diverse p53 mutants
A. R. Blanden, X. Yu, A. J. Blayney…·S. N. Loh
This paper develops a thermodynamic model to analyze how p53 mutations affect zinc binding and stability, showing that synthetic zinc metallochaperones can reactivate diverse p53 mutants.
DOI 10.7554/elife.61487