ImmunologybioRxivPreprint
Natural IgA and TNFRSF13B polymorphism: a double edged sword fueling balancing selection
J. L. Platt, M. G. de Mattos Barbosa, D. Huynh…·M. Cascalho
The paper investigates how a dominant-negative variant of TNFRSF13B confers resistance to enteric pathogens by reducing natural IgA, suggesting balancing selection due to its dual role in immunity and pathogenesis.
DOI 10.1101/2021.01.29.428850