Author

M. Cascalho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Organism:non-human primate· 1

Frequent Co-Authors

M. G. de Mattos Barbosa· 2 shared A. A. Kennedy· 1 shared A. David· 1 shared A. R. Leferts· 1 shared A. Shikanov· 1 shared A. Tarantal· 1 shared A. W. Tai· 1 shared C. E. Wobus· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

M. G. de Mattos Barbosa

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Author profile →

3 papers

Recent·Most cited

Encapsulated allografts preclude host sensitization and promote ovarian endocrine function in ovariectomized young rhesus monkeys and sensitized mice

J. R. Day, C. L. Flanagan, A. David, D. J. Hartigan-O'Connor, M. G. de Mattos Barbosa, M. L. Martinez, C. Lee, J. Barnes, E. Farkash, M. Zelinski, A. Tarantal, M. Cascalho, A. Shikanov

This study shows that encapsulating ovarian allografts prevents immune sensitization and maintains endocrine function in both mice and rhesus monkeys.

bioRxiv · Jun 10, 2021Bioengineering

A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine

S. Jangra, J. J. Landers, R. Rathnasinghe, J. J. O'Konek, K. W. Janczak, M. Cascalho, A. A. Kennedy, A. W. Tai, J. R. Baker, M. Schotsaert, P. T. Wong

This study develops a combination adjuvant that enhances antiviral immune responses to a SARS-CoV-2 protein vaccine, showing improved TH1 responses and neutralizing antibodies against variants in mice.

bioRxiv · Feb 18, 2021Immunology

Natural IgA and TNFRSF13B polymorphism: a double edged sword fueling balancing selection

J. L. Platt, M. G. de Mattos Barbosa, D. Huynh, A. R. Leferts, J. Katta, C. Kharas, P. Freddolino, C. M. Bassis, C. E. Wobus, R. Geha, R. J. Bram, G. Nunez, N. Kamada, M. Cascalho

The paper investigates how a dominant-negative variant of TNFRSF13B confers resistance to enteric pathogens by reducing natural IgA, suggesting balancing selection due to its dual role in immunity and pathogenesis.

bioRxiv · Jan 29, 2021 · PreprintImmunology