A. R. Satoskar

This study shows that Leishmania mexicana centrin knockout parasites induce M1-polarizing metabolic changes through enhanced pentose phosphate pathway activity, promoting pro-inflammatory responses.

This study identifies anti-nociceptive metabolic pathways upregulated in Leishmania mexicana infection, including purines and endocannabinoids, which may explain the painless nature of cutaneous leishmaniasis lesions.

This study uses dual scRNA-seq to identify rare parasitized cell populations in L. donovani infection, revealing HSCs as dominant in bone marrow and new infected cell types in spleen.

This study shows that centrin-deficient L. mexicana parasites protect against Old World visceral leishmaniasis in a hamster model by reducing parasite burden and altering cytokine responses.

This study shows that a genetically modified Leishmania vaccine generates skin-resident memory T cells that provide protection similar to leishmanization.