P. Bhattacharya

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

Analysis of Factors Determining Success in FFPE Based NGS Panel Testing For Lung & Ovarian Cancer

This study identifies pre-analytic factors affecting NGS success in FFPE samples for lung and ovarian cancer, highlighting DNA quality, sample type, and fixation time as key predictors.

Dual scRNA-Seq analysis reveals rare and uncommon parasitized cell populations in chronic L. donovani infection

This study uses dual scRNA-seq to identify rare parasitized cell populations in L. donovani infection, revealing HSCs as dominant in bone marrow and new infected cell types in spleen.

Skin resident memory cells generated by the L. major centrin gene deleted parasites mediate protective immune response analogous to leishmanization

This study shows that a genetically modified Leishmania vaccine generates skin-resident memory T cells that provide protection similar to leishmanization.

HIV-1 Induction of Tolerogenic DCs is Mediated by Cellular Interaction with Suppressive T Cells

The paper investigates how HIV-1 exposure affects dendritic cells (DCs) through interaction with suppressive T cells, showing increased tolerogenic markers and type I IFN response.

Unravelling cotton RNAseq repositories to the fiber development specific modules and their alliance with the fiber-related traits

The paper analyzes RNAseq data from cotton to identify gene modules associated with fiber development stages and links them to fiber-related traits.

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

Hypercholesterolemia Impairs Clearance of Extracellular DNA and Promotes Inflammation and Atherosclerotic Plaque Progression

This study shows hypercholesterolemia impairs DNA clearance by reducing DNase activity, leading to inflammation and atherosclerosis progression in mice and humans.

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

The paper identifies 5,6-dihydroxyindole (DHI) as a dopamine metabolite that covalently modifies and activates Nurr1, a nuclear receptor critical for dopaminergic neuron function, offering potential therapeutic strategies for Parkinson's disease.