MicrobiologybioRxiv
Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine
Q. Wang, Y. Guo, A. R. Tam…·D. D. Ho
This study shows that the ancestral spike in bivalent COVID-19 vaccines causes deep immunological imprinting, limiting antibody breadth against Omicron subvariants.
DOI 10.1016/j.xcrm.2023.101258