P. Castro-Sanchez

Phosphatases of regenerating liver balance F-actin rearrangements during T cell activation through WD repeat containing protein 1

This study shows that PRLs regulate F-actin dynamics during T cell activation by interacting with WDR1, affecting IS formation and cytokine production.

Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion

This study shows that deleting PTPN22 in T cells enhances initial anti-tumor effector function but accelerates T cell exhaustion, with TIM-3 expression linked to IL-2 signaling and NFIL3.