Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer's disease in mice
P. Makhijani, R. Emani, C. G. Aguirre, W.-C. Mu, A. Rane, J. H. Y. Ng, T. R. Valentino, M. Manwaring-Mueller, C. R. Tan, H. Du, F. Wu, S. Khan, K. A. Wilson, S. Winer, C. Wang, , D. A. Winer
This study uses single-cell RNA sequencing to identify immune changes in the colon of Alzheimer's disease mice, finding reduced antibody-secreting cells and altered immune trafficking.
bioRxiv · Jan 27, 2024 · PreprintImmunology