Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration
A. B. Ball, A. E. Jones, K. B. Nguyen, A. Rios, N. Marx, W. Y. Hsieh, K. Yang, B. R. Desousa, K. K. O. Kim, M. Veliova, Z. M. del Mundo, O. S. Shirihai, C. Beninca, L. Stiles, S. J. Bensinger, A. S. Divakaruni
This study shows that reduced oxidative phosphorylation is not required for pro-inflammatory macrophage activation, challenging the conventional model of mitochondrial reprogramming.
bioRxiv · May 10, 2024 · PreprintImmunology