Memory-like B cells emerging from germinal centres recycle through the subcapsular sinus
Y. Zhang, L. Garcia-Ibanez, C. Ulbricht, L. S. C. Lok, T. W. Dennison, J. R. Ferdinand, J. Mueller-Winkler, C. J. M. Burnett, J. C. Yam-Puc, L. Zhang, G. Brown, V. Tybulewicz, A. Rot, A. E. Hauser, M. R. Clatworthy, K.-M. Toellner
The paper tracks B cells exiting germinal centers and shows they recycle through the subcapsular sinus, interacting with macrophages and returning to GCs via CCL21 gradients, supporting affinity maturation to antigenic drift.
bioRxiv · Dec 8, 2020 · PreprintImmunology