A. Shemesh

Spleen Tyrosine Kinase (SYK) negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy

This study shows that SYK negatively regulates NK cell signaling and that its deletion enhances CD19-CAR NK cell efficacy in cancer immunotherapy.

CITE-seq analysis reveals human cytomegalovirus and diabetes-associated adaptive NK cell alterations in cardiovascular disease.

The paper uses CITE-seq to analyze NK cell alterations in CAD patients, finding SPON2/IFNG ratio and adaptive NK cell signatures correlate with disease severity and inflammation.

Coordination between cytoskeletal organization, cell contraction and extracellular matrix development, is depended on LOX for aneurysm prevention

This study shows LOX is essential for coordinating cytoskeletal organization, cell contraction, and ECM development to prevent aneurysms.

Ribosomal Protein SA (RPSA) is required for localized translation and sarcomere maintenance in mice

This study shows RPSA is necessary for ribosome localization to Z-lines and local translation, which supports sarcomere maintenance in mice.

Sex differences in coronary artery disease and diabetes revealed by scRNA-Seq and CITE-Seq of human CD4+ T cells

The paper uses scRNA-Seq and CITE-Seq to analyze CD4+ T cells from patients with and without coronary artery disease and diabetes, identifying sex-specific differences and gene expression patterns.

Natural Killer cell division regulates FcεRIγ expression downstream of mTOR activity

The paper shows that NK cell division and mTOR activity regulate FcRγ expression, with rapamycin and TGFβ reducing FcRγ levels by suppressing division.

Combined protein and transcript single cell RNA sequencing in human peripheral blood mononuclear cells

The paper develops combined protein and transcript single-cell RNA sequencing in PBMCs, identifying more cell subsets than traditional methods and showing disease-related transcriptome differences in HIV patients.