P. Roy

mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migration

This study identifies mDia2 as a mediator of MRTF-A-dependent breast cancer cell migration and links MRTF activity to malignancy, suggesting it as a therapeutic target.

Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner

This study shows that MRTF in breast cancer cells promotes osteoclast differentiation via paracrine signaling, enhancing bone metastasis, and suggests MRTF inhibition as a potential therapeutic strategy.

Haplo-insufficiency of Profilin1 in vascular endothelial cells is beneficial but not sufficient to confer protection against experimentally induced atherosclerosis

This study shows that partial loss of Profilin1 in vascular endothelial cells has some protective effects against atherosclerosis but is not enough to fully prevent it.

Motif-VI Loop Acts as a Nucleotide Valve in the West Nile Virus NS3 Helicase

This study identifies the motif-VI loop as a nucleotide valve in the West Nile Virus NS3 helicase, showing its role in ATP hydrolysis and viral replication through molecular simulations and experimental validation.

Idiosyncrasies unveiled: examining the pace, patterns and predictors of biotic diversification in peninsular India

The paper examines diversification rates and drivers in Peninsular India's endemic lineages using molecular phylogenies and birth-death models, finding angiosperms diversified fastest and Miocene climate changes influenced patterns in some lineages.

The Role of ATP Hydrolysis and Product Release in the Translocation Mechanism of SARS-CoV-2 NSP13

This paper investigates the ATP hydrolysis and product release mechanism of SARS-CoV-2 NSP13 using molecular dynamics simulations and identifies key residues involved in RNA translocation.

Sex differences in coronary artery disease and diabetes revealed by scRNA-Seq and CITE-Seq of human CD4+ T cells

The paper uses scRNA-Seq and CITE-Seq to analyze CD4+ T cells from patients with and without coronary artery disease and diabetes, identifying sex-specific differences and gene expression patterns.

Nementin is a Nematode-Selective Small Molecule Agonist of Neurotransmitter Release

A C. elegans-based screening pipeline identifies a selective nematicide that also potentiates acetylcholinesterase inhibitors.

Selective Control of Parasitic Nematodes Using Bioactivated Nematicides

This study identifies selectivins, a family of imidazothiazole nematicides that are selectively activated in nematodes, offering effective and selective control of plant-parasitic nematodes.

SARS-CoV-2 Virus like Particles produced by a single recombinant baculovirus generate potent neutralizing antibody that protects against variant challenge

This study generates SARS-CoV-2 virus-like particles using baculovirus expression, showing they induce neutralizing antibodies and protect against variant challenge in a hamster model.

High-throughput small molecule screen identifies inhibitors of microsporidia invasion and proliferation in C. elegans.

This study screens FDA-approved compounds and natural products to identify inhibitors of microsporidia infection in C. elegans, finding five compounds that block spore firing and one that slows infection progression.

Altered DNA methylation in ion transport and immune signalling genes is associated with severity in Pancreatic Ductal Adenocarcinoma

This study identifies DNA methylation changes in PDAC associated with disease severity and finds concordance with TCGA-PAAD and GTEx datasets.

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses

The paper performs bidirectional CRISPR screens to identify host factors regulating SARS-CoV-2, MERS-CoV, and seasonal coronaviruses, revealing new anti-viral proteins and general coronavirus cofactors.

The plant circadian clock gene LHY influences Medicago truncatula nodulation

This study shows that the circadian clock gene LHY in Medicago truncatula influences nodulation and rhythmic expression of NCR genes, which may coordinate bacterial activity with plant rhythms for optimal symbiosis.

Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

The paper identifies parallel seasonal allele frequency shifts in Drosophila melanogaster across North America and Europe, linking environmental conditions to genomic responses to selection.

Disulfide reduction allosterically destabilizes the β-ladder sub-domain assembly within the NS1 dimer of ZIKV

This paper shows that reducing disulfide bonds in ZIKV NS1 protein destabilizes its dimer structure, leading to asymmetry and reduced virulence.

Combined protein and transcript single cell RNA sequencing in human peripheral blood mononuclear cells

The paper develops combined protein and transcript single-cell RNA sequencing in PBMCs, identifying more cell subsets than traditional methods and showing disease-related transcriptome differences in HIV patients.

A non enveloped arbovirus released in lysosome-derived extracellular vesicles induces super infection exclusion

This study shows non-enveloped Bluetongue virus is mainly released in lysosome-derived extracellular vesicles, which are more infectious but trigger super-infection exclusion, unlike free-viruses.

Desmin is a modifier of dystrophic muscle features in Mdx mice

This study shows that desmin deletion in Mdx mice worsens muscle weakness, fragility, and fatigue resistance, while desmin gene transfer improves these features.