Author

K. Ley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:experimental assay· 7 Organism:human· 5 Organism:mouse· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

A. Shemesh· 3 shared C. C. Hedrick· 3 shared L. L. Lanier· 3 shared C. A. McNamara· 2 shared C. P. Durant· 2 shared E. Ehinger· 2 shared J. Vallejo· 2 shared P. Roy· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. Shemesh

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

CITE-seq analysis reveals human cytomegalovirus and diabetes-associated adaptive NK cell alterations in cardiovascular disease.

S. S. Armstrong, D. G. Chen, S. Kumar, J. R. Heath, M. Feinstein, J. R. Greenland, D. R. Calabrese, L. L. Lanier, K. Ley, A. Shemesh

The paper uses CITE-seq to analyze NK cell alterations in CAD patients, finding SPON2/IFNG ratio and adaptive NK cell signatures correlate with disease severity and inflammation.

bioRxiv · Mar 22, 2024 · PreprintImmunology

Sex differences in coronary artery disease and diabetes revealed by scRNA-Seq and CITE-Seq of human CD4+ T cells

R. Saigusa, J. Vallejo, R. Gulati, S. S. A. Suthahar, V. Suryawanshi, A. Alimadadi, J. Makings, C. P. Durant, A. Freuchet, P. Roy, Y. Ghosheh, W. Pandori, T. Pattarabanjird, F. Drago, C. A. McNamara, , K. Ley

The paper uses scRNA-Seq and CITE-Seq to analyze CD4+ T cells from patients with and without coronary artery disease and diabetes, identifying sex-specific differences and gene expression patterns.

bioRxiv · May 16, 2022Immunology

Integrated scRNA-seq analysis identifies conserved transcriptomic features of mononuclear phagocytes in mouse and human atherosclerosis

A. Zernecke, F. Erhard, T. Weinberger, C. Schulz, K. Ley, A.-E. Saliba, C. Cochain

This study integrates scRNA-seq data from mouse and human atherosclerosis to identify conserved transcriptomic features of mononuclear phagocytes across species.

bioRxiv · Dec 9, 2020Immunology

Combined protein and transcript single cell RNA sequencing in human peripheral blood mononuclear cells

J. Vallejo, R. Saigusa, R. Gulati, Y. Ghosheh, C. P. Durant, P. Roy, E. Ehinger, T. Pattarabanjird, L. E. Padgett, C. E. Olingy, D. B. Hanna, A. L. Landay, R. P. Tracy, J. M. Lazar, W. J. Mack, , K. Ley

The paper develops combined protein and transcript single-cell RNA sequencing in PBMCs, identifying more cell subsets than traditional methods and showing disease-related transcriptome differences in HIV patients.

bioRxiv · Sep 10, 2020Immunology

CD45 pre-exclusion from the tips of microvilli establishes a phosphatase-free zone for early TCR triggering

Y. Jung, L. Wen, A. Altman, K. Ley

The paper shows CD45 is pre-excluded from microvilli tips on T cells, enabling early TCR triggering before stable immunological synapse formation.

bioRxiv · May 21, 2020Immunology

Selective augmentation of intestinal immunity by CD22-dependent SHP-1 control of β7 integrin expression.

R. Ballet, C. Brandl, N. Feng, J. Berri, J. Cheng, B. Ocon, A. Alborzian Deh Sheikh, A. Marki, C. L. Abram, C. A. Lowell, T. Tsubata, H. B. Greenberg, M. S. Macauley, K. Ley, L. Nitschke, E. Butcher

This study identifies CD22-dependent SHP-1 regulation of β7 integrin expression, showing its role in intestinal immunity and pathogen clearance.

bioRxiv · Jan 31, 2020 · PreprintImmunology

A Rap1 binding site and lipid-dependent helix in talin F1 domain promote integrin activation in tandem

A. Gingras, F. Lagarrigue, M. Cuevas, M. Zorovich, A. Valadez, M. A. Lopez-Ramirez, N. Seban, W. McLaughlin, K. Ley, W. Kiosses, M. Ginsberg

The paper identifies a novel Rap1 binding site in talin1 F1 domain and shows its cooperation with a lipid-dependent amphipathic helix to enable integrin activation.

bioRxiv · Apr 13, 2019Cell Biology

Bone marrow transplantation rescues monocyte recruitment defect and improves cystic fibrosis in mice

Z. Fan, J. Miller, R. Herro, E. Ehinger, D. J. Conrad, Z. Mikulski, Y. P. Zhu, P. M. Marcovecchio, C. C. Hedrick, K. Ley

This study shows bone marrow transplantation improves survival and reduces inflammation in CFTRΔF508 mice by rescuing monocyte adhesion defects.

bioRxiv · Mar 6, 2019Immunology

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

J. G. Burel, M. Pomaznoy, C. S. Lindestam Arlehamn, D. Weiskopf, R. da Silva Antunes, Y. Jung, V. Schulten, M. Babor, G. Seumois, J. A. Greenbaum, S. Premawansa, G. Premawansa, A. Wijewickrama, D. Vidanagama, B. Gunasena, , B. Peters

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.

bioRxiv · Feb 21, 2019 · PreprintImmunology