PhysiologybioRxiv
Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5
Z. Wang, S. H. Vermij, V. Sottas…·H. Abriel
This study identifies calmodulin as a new binding partner of the Nav1.5 N-terminal domain and shows that mutations in this region impair the interaction, contributing to dominant-negative effects in Brugada Syndrome.
DOI 10.1080/19336950.2020.1805999