Author

D. Ross-Kaschitza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:electrophysiology· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

H. Abriel· 4 shared J.-S. Rougier· 4 shared M. Lochner· 2 shared P. Arullampalam· 2 shared S. Guichard· 2 shared A. Hudmon· 1 shared A. Seljmani· 1 shared A. Shestak· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiochemistry

H. Abriel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4

B. Ekundayo, P. Arullampalam, C. Gerber, A.-F. Haemmerli, S. Guichard, M. Boukenna, D. Ross-Kaschitza, M. Lochner, J.-S. Rougier, H. Stahlberg, H. Abriel, D. Ni

The paper identifies the binding site of small molecule inhibitors NBA and IBA in TRPM4 using cryo-EM and patch clamp experiments.

bioRxiv · Jan 22, 2024Biochemistry

Role of 14-3-3 proteins in human cardiac sodium channel Nav1.5 regulation

O. Iamshanova, A.-F. Hämmerli, E. Ramaye, A. Seljmani, D. Ross-Kaschitza, N. Schärz, M. Essers, S. Guichard, J.-S. Rougier, H. Abriel

This study investigates the role of 14-3-3 proteins in regulating the human cardiac sodium channel Nav1.5 using heterologous expression in tsA201 cells and finds no significant regulatory effect.

bioRxiv · Oct 26, 2022Biophysics

Species-specific effects of cation channel TRPM4 small-molecule inhibitors

P. Arullampalam, B. Preti, D. Ross-Kaschitza, M. Lochner, J.-S. Rougier, H. Abriel

This study compares the effects of TRPM4 inhibitors on human and mouse TRPM4 channels, revealing species-specific responses and highlighting the need for in vivo validation.

bioRxiv · Jun 1, 2021Pharmacology & Toxicology

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5

Z. Wang, S. H. Vermij, V. Sottas, A. Shestak, D. Ross-Kaschitza, E. V. Zaklyazminskaya, A. Hudmon, G. S. Pitt, J.-S. Rougier, H. Abriel

This study identifies calmodulin as a new binding partner of the Nav1.5 N-terminal domain and shows that mutations in this region impair the interaction, contributing to dominant-negative effects in Brugada Syndrome.

bioRxiv · Jun 2, 2020Physiology