Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19
D. Ashok, T. Liu, J. Criscione, M. Prakash, B. Kim, J. Chow, M. Craney, K. Papanicolaou, A. Sidor, D. B. Foster, A. Pekosz, J. Villano, D.-H. Kim, B. O'Rourke
This study shows that SARS-CoV-2 infection causes persistent cardiac conduction system dysfunction in hamsters, driven by innate immune activation and mitochondrial ROS, with potential implications for long COVID.
bioRxiv · Jan 5, 2024Pathology