Author

D. Ashok

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

B. O'Rourke· 3 shared A. Pekosz· 1 shared A. Sidor· 1 shared B. Dunkerly-Eyring· 1 shared B. Kim· 1 shared C. U. Oeing· 1 shared D. A. Kass· 1 shared D. B. Foster· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPathology

B. O'Rourke

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19

D. Ashok, T. Liu, J. Criscione, M. Prakash, B. Kim, J. Chow, M. Craney, K. Papanicolaou, A. Sidor, D. B. Foster, A. Pekosz, J. Villano, D.-H. Kim, B. O'Rourke

This study shows that SARS-CoV-2 infection causes persistent cardiac conduction system dysfunction in hamsters, driven by innate immune activation and mitochondrial ROS, with potential implications for long COVID.

bioRxiv · Jan 5, 2024Pathology

PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

S. Mishra, V. Hahn, N. Sadagopan, B. Dunkerly-Eyring, S. Rodriguez, D. C. Sarver, R. P. Ceddia, S. Murphy, H. Knutsdottir, V. Jani, D. Ashok, C. U. Oeing, B. O'Rourke, K. Sharma, J. Gangoiti, , D. A. Kass

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

bioRxiv · Feb 2, 2021 · PreprintPhysiology

MitoWave: Spatiotemporal analysis of mitochondrial membrane potential fluctuations during ischemia-reperfusion

B. O'Rourke, D. Ashok

This paper introduces MitoWave, a tool to analyze mitochondrial membrane potential fluctuations during ischemia-reperfusion, showing significant differences in oscillatory behavior and correlations between frequency and cluster area.

bioRxiv · May 21, 2020 · PreprintCell Biology