J. Chow

Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19

This study shows that SARS-CoV-2 infection causes persistent cardiac conduction system dysfunction in hamsters, driven by innate immune activation and mitochondrial ROS, with potential implications for long COVID.

The first archaeal PET-degrading enzyme belongs to the feruloyl-esterase family

The paper identifies and characterizes PET46, an archaeal feruloyl esterase capable of degrading PET, expanding the known diversity of PET-hydrolyzing enzymes.

Lamellar Thickness Measurements in Normal and Osteogenesis Imperfecta Human Bone, with development of a method of automated thickness averaging to simplify quantitation.

This study quantifies lamellar thickness in normal and osteogenesis imperfecta (OI) bone using polarization light microscopy and develops an automated method to improve measurement accuracy and efficiency.

Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates

This study shows butyrate reduces C. difficile fitness in mice and humans, and inhibits growth of diverse C. difficile isolates, suggesting dietary interventions could help prevent CDI.

Micro-region transcriptomics of fixed human tissue using Pick-Seq

Pick-Seq enables deep spatial transcriptomic profiling of fixed human tissue, revealing transcriptional differences in tumor invasion, proliferation, and immuno-editing.

Regulation of Bud Emergence by a MAPK Pathway

This study shows the MAPK pathway regulates bud emergence in yeast under nutrient-limiting conditions by modulating Cdc42p activity and polarity targets.