Author

A. Sintsova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Research Focus:host-pathogen & immune response· 3 Organism:Drosophila· 2 Organism:E. coli· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

H. L. T. Mobley· 3 shared S. N. Smith· 3 shared A. Chavan· 2 shared A. E. Frick-Cheng· 2 shared A. Pirani· 2 shared E. S. Snitkin· 2 shared F. Uliana· 2 shared M. Jagannathan· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

H. L. T. Mobley

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Author profile →

6 papers

Recent·Most cited

A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate

A. Chavan, R. Isenhart, S. C. Nguyen, N. Kotb, J. Harke, A. Sintsova, G. Ulukaya, F. Uliana, C. Ashiono, U. Kutay, G. Pegoraro, P. Rangan, E. F. Joyce, M. Jagannathan

The paper identifies Stonewall as a protein that positions chromatin at the nuclear periphery in Drosophila, linking this positioning to gene repression and germline stem cell fate.

bioRxiv · Nov 17, 2023Cell Biology

Multi-tissue proteomics identifies a link between satellite DNA organization and heritable transposon repression in Drosophila

A. Chavan, L. Skrutl, F. Uliana, M. Pfister, F. Braendle, L. Tirian, D. Baptista, D. Handler, D. F. Burke, A. Sintsova, P. Beltrao, J. Brennecke, M. Jagannathan

bioRxiv · Jul 11, 2023 · PreprintCell Biology

Ferric Citrate Uptake is a Virulence Factor in Uropathogenic Escherichia coli

A. E. Frick-Cheng, A. Sintsova, S. N. Smith, A. Pirani, E. S. Snitkin, H. L. T. Mobley

This study identifies the ferric citrate uptake system as a virulence factor in UPEC, showing its role in iron acquisition during UTI and its importance for bacterial fitness.

bioRxiv · Nov 12, 2021Microbiology

The Gene Expression Profile of Uropathogenic Escherichia coli in Women with Uncomplicated Urinary Tract Infections Is Recapitulated in the Mouse Model

A. E. Frick-Cheng, A. Sintsova, S. N. Smith, M. Krauthammer, K. A. Eaton, H. L. T. Mobley

This study compares gene expression of UPEC in human UTIs and a mouse model, finding strong correlation and validating the mouse model's utility for UTI research.

mBio · Aug 25, 2020Peer-reviewedMicrobiology

Optimization of an Experimental Vaccine to Prevent Escherichia coli Urinary Tract Infection

V. S. Forsyth, S. D. Himpsl, S. N. Smith, C. A. Sarkissan, L. A. Mike, J. A. Stocki, A. Sintsova, C. Alteri, H. L. T. Mobley

This study optimizes an intranasal vaccine against UPEC UTI using dmLT adjuvant and Hma/IutA antigens, significantly reducing bladder colonization.

mBio · Apr 28, 2020Peer-reviewedMicrobiology

Genetically diverse uropathogenic Escherichia coli adopt a common transcriptional program in patients with urinary tract infections

A. Sintsova, A. Frick-Cheng, S. Smith, A. Pirani, S. Subashchandrabose, E. S. Snitkin, H. Mobley

The paper identifies a common transcriptional program in genetically diverse UPEC strains from UTI patients, marked by upregulated translational machinery and specialized catabolism.

bioRxiv · Mar 31, 2019Microbiology