F. Uliana

A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate

The paper identifies Stonewall as a protein that positions chromatin at the nuclear periphery in Drosophila, linking this positioning to gene repression and germline stem cell fate.

The hGID GID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration

This study identifies GID4 as a substrate receptor of the hGID E3 ligase complex that targets ARHGAP11A for degradation, thereby regulating cell migration.

Multi-tissue proteomics identifies a link between satellite DNA organization and heritable transposon repression in Drosophila

Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics

The paper determines the cryo-EM structure of bovine AC8 bound to CaM and Gs, identifies interaction sites, and infers conformational changes in the regulation mechanism.

Cell cycle progression defects and impaired DNA damage signaling drive enlarged cells into senescence

This study shows that enlarged cells have increased DNA damage and impaired repair, leading to senescence.

An amphipathic helix in Brl1 is required for membrane fusion during nuclear pore complex biogenesis in S. cerevisiae

This study identifies Brl1's amphipathic helix as essential for NE fusion during NPC biogenesis in yeast.

Glucose stress causes mRNA retention in nuclear Nab2 condensates

The paper shows glucose stress causes mRNA retention in nuclear Nab2 condensates by forming RNA-dependent structures, affecting mRNA export and gene expression.

Human -Synuclein Inhibits Platelets Aggregation in vitro by Interfering with the -Thrombin/Protease-Activated Receptor 1 Functional Axis

This study shows that human -synuclein inhibits platelet aggregation by interfering with the -thrombin/PAR1 functional axis through direct and indirect mechanisms.

Mapping specificity, entropy, allosteric changes and substrates in blood proteases by a high-throughput protease screen

The paper introduces a high-throughput proteomic method to profile protease activity and substrate specificity in native conditions, achieving high throughput and accuracy.