P. Beltrao

The paper identifies two distinct nuclear pore complex remodeling events during budding yeast meiosis, revealing conserved mechanisms of nuclear basket organization.

This study assesses AlphaFold 2's applications in structural biology, finding it outperforms existing tools in predicting disorder, complexes, and structural features with high confidence.

This study characterizes clinical and molecular features of acquired resistance to PD-(L)1 blockade in NSCLC, identifying persistent inflammation and dysfunctional IFN signaling as key features.

The paper analyzes protein activity changes in cancer using genomics and proteomics data to identify drivers of signaling dysregulation and their impact on patient survival.

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

This study identifies iron uptake systems, particularly the high-pathogenicity island, as key drivers of extra-intestinal virulence in Escherichia through a genome-wide association analysis in a mouse sepsis model.

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

The paper investigates the evolution of kinase substrate recognition, showing early sequence variation in specificity residues and stability of specificity in recent duplications, with phosphorylation motifs broadly distributed in eukaryotes.

The paper identifies 30 putative specificity determinant residues in protein kinases and shows their conservation and mutation patterns in cancer and evolution.

The paper identifies conserved phosphorylation hotspots across 40 eukaryotic species and shows their functional importance in protein domains.

This study identifies phosphoregulation networks during Plasmodium gamete formation using high-resolution phosphoproteomics.