Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription
A. dos Santos, D. E. Rollins, Y. Hari-Gupta, H. C. Reed, M. Du, S. Y. Z. Ru, K. Pidlisna, A. Stranger, F. Lorgat, I. Brown, K. Howland, J. Arron, L. Wang, P. J. Ellis, T. L. Chew, , C. P. Toseland
This study identifies NDP52's role in modulating RNA Polymerase II transcription by altering DNA conformation through direct dsDNA binding and interactions with chromatin regulators.
bioRxiv · Feb 1, 2022 · PreprintBiophysics