The hepatic compensatory response to elevated systemic sulfide promotes diabetes
R. N. Carter, M. T. G. Gibbins, M. E. Barrios-Llerena, S. E. Wilkie, P. L. Freddolino, M. Libiad, V. Vitvitsky, B. Emerson, T. Le Bihan, M. Brice, H. Su, S. G. Denham, N. Z. M. Homer, C. Mc Fadden, A. Tailleux, , N. M. Morton
This study shows that mice lacking the sulfide oxidation pathway enzyme TST exhibit metabolic abnormalities despite insulin sensitization, highlighting TST's role in hepatic metabolism and potential implications for sulfide-donor therapies.
bioRxiv · Apr 27, 2020Physiology