HER2 overexpression initiates breast tumorigenesis non-cell-autonomously by inducing oxidative stress in the tissue microenvironment
S. B. Gurler, O. Wagstaff, L. Dimitrova, F. Chen, R. Pedley, W. Weston, I. Donaldson, B. A. Telfer, D. Novo, K. Pavlou, G. Taylor, Y. Ou, K. J. Williams, A. P. Gilmore, K. Brennan, A. Ucar
This study shows HER2 overexpression drives breast tumorigenesis by inducing oxidative stress in the tissue microenvironment, not directly in cancer stem cells.
bioRxiv · Aug 25, 2023 · PreprintCancer Biology