Y. Ou

HER2 overexpression initiates breast tumorigenesis non-cell-autonomously by inducing oxidative stress in the tissue microenvironment

This study shows HER2 overexpression drives breast tumorigenesis by inducing oxidative stress in the tissue microenvironment, not directly in cancer stem cells.

Can deep learning predict human intelligence from structural brain MRI?

This study uses deep learning on structural brain MRI to predict individual intelligence quotients, showing statistical significance in predicting verbal, comprehensive, and full-scale IQ.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans

The paper analyzes chemokine gene expression across species, tissues, and diseases, showing complex patterns and demonstrates that ECM proteoglycans modulate chemokine signaling and leukocyte recruitment.

Synergistic anti-phage activity of bacterial defence systems

The paper investigates bacterial defence systems against phage predation, finding synergistic anti-phage activity and compatibility between systems in different bacterial taxa.

Amyloid β-peptide impacts on glucose regulation are dependent on apolipoprotein E genotype

This study shows that Aβ impacts glucose regulation differently in ApoE3 and ApoE4 mice, with ApoE4 showing less exacerbation of Aβ effects on glucose tolerance.

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

High Frequency of Dynamic Rearrangements in CRISPR Loci

This study identifies frequent dynamic rearrangements in CRISPR loci across prokaryotic genomes, challenging the idea that spacer order reflects infection timing.

Bioprinting microporous functional living materials from protein-based core-shell microgels

This paper introduces a core-shell microgel bioprinting method to create functional living materials with controlled microporosity and enhanced bioprocessing capabilities.

Analysis of genetic signatures of tumor microenvironment yields insight into mechanisms of resistance to immunotherapy

The paper identifies genetic signatures in tumor microenvironments to explain resistance to immunotherapy and suggests potential therapeutic strategies.

Pan-cancer analysis identified inflamed microenvironment associated multi-omics signatures

The paper identifies molecular signatures of inflamed and non-inflamed tumor microenvironments across cancers and suggests potential drugs to convert non-inflamed tumors to inflamed ones.