Author

R. Pedley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. P. Gilmore· 4 shared J. Swift· 3 shared K. Brennan· 2 shared V. Mallikarjun· 2 shared A. Ucar· 1 shared B. A. Telfer· 1 shared D. Novo· 1 shared D. T. Prescott· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCancer Biology

A. P. Gilmore

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4 papers

Recent·Most cited

HER2 overexpression initiates breast tumorigenesis non-cell-autonomously by inducing oxidative stress in the tissue microenvironment

S. B. Gurler, O. Wagstaff, L. Dimitrova, F. Chen, R. Pedley, W. Weston, I. Donaldson, B. A. Telfer, D. Novo, K. Pavlou, G. Taylor, Y. Ou, K. J. Williams, A. P. Gilmore, K. Brennan, A. Ucar

This study shows HER2 overexpression drives breast tumorigenesis by inducing oxidative stress in the tissue microenvironment, not directly in cancer stem cells.

bioRxiv · Aug 25, 2023 · PreprintCancer Biology

Novel Laser Capture Microdissection-Proteomic Analysis Identifies Spatially Distinct Extracellular Matrix Signatures in the Core and Infiltrating Edge of Human Glioblastoma.

R. Pedley, D. T. Prescott, E. Appleton, L. Dingle, J. Minshull, P. I. D'Urso, I. Djoukhadar, A. P. Gilmore, F. Roncaroli, J. Swift

This paper develops an LCM-proteomics protocol to analyze spatial ECM differences in human glioblastoma, identifying distinct matrisome components between tumor epicenter and brain/tumor interface.

bioRxiv · Sep 1, 2022 · PreprintCancer Biology

BioID based proteomic analysis of the Bid interactome identifies novel proteins involved in cell cycle dependent apoptotic priming.

R. Pedley, L. King, V. Mallikarjun, P. Wang, J. Swift, K. Brennan, A. P. Gilmore

The paper uses BioID to identify novel Bid interactors involved in cell cycle-dependent apoptotic priming, highlighting VDAC2's role in Bid phosphorylation and sensitivity to anti-mitotic drugs.

bioRxiv · Feb 7, 2020Cell Biology

Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading

H. T. Gilbert, V. Mallikarjun, O. Dobre, M. R. Jackson, R. Pedley, A. P. Gilmore, S. M. Richardson, J. Swift

The paper investigates how human mesenchymal stem cells respond to mechanical loading by decoupling nuclear and cytoskeletal mechano-transmission at the protein level.

bioRxiv · May 9, 2018Biophysics