K. Brennan

HER2 overexpression initiates breast tumorigenesis non-cell-autonomously by inducing oxidative stress in the tissue microenvironment

This study shows HER2 overexpression drives breast tumorigenesis by inducing oxidative stress in the tissue microenvironment, not directly in cancer stem cells.

Epigenetic silencing by SMYD3 represses tumor intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck.

This study identifies SMYD3 as an epigenetic regulator that suppresses the intrinsic interferon response in HPV-negative HNSCC, offering a potential strategy to enhance immunotherapy response.

Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue

This study shows that kRasV12 oncogene-expressing clusters induce anisotropic strain in host tissue, increasing cell division and altering division orientation, which can be reversed by reducing actomyosin contractility.

Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease

This study shows that PKC loss increases uremia-induced arterial medial calcification in mice, suggesting PKC/TGF-β signaling as a therapeutic target.

Inhibition of Wnt signalling by Notch via two distinct mechanisms

The paper identifies two distinct mechanisms by which Notch inhibits Wnt signaling by limiting β-catenin transcriptional activity in vertebrate cells.

BioID based proteomic analysis of the Bid interactome identifies novel proteins involved in cell cycle dependent apoptotic priming.

The paper uses BioID to identify novel Bid interactors involved in cell cycle-dependent apoptotic priming, highlighting VDAC2's role in Bid phosphorylation and sensitivity to anti-mitotic drugs.

TGFβ drives mitochondrial dysfunction in peripheral blood NK cells during metastatic breast cancer

This study shows that TGFβ causes mitochondrial dysfunction in NK cells of metastatic breast cancer patients, and blocking TGFβ improves their metabolic function and IFNγ production.

An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness

The paper shows that an immortalized mesenchymal stem cell line retains mechano-responsiveness and can serve as a reporter for substrate stiffness.

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma

This study identifies an NSD1-inactivated, DNA hypomethylated, immune cold subtype in lung and head and neck squamous cell carcinomas, linked to poor immune infiltration and potential immunotherapy resistance.